bms 202 (MedChemExpress)

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MedChemExpress bms 202
Bms 202, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 34 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/bms+202/BMS-202/pm41874277-263-24-25
Average 94 stars, based on 34 article reviews

bms 202 - by Bioz Stars, 2026-09

94/100 stars

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Blocking Assay:

Article Title: Direct effects of the small molecule PD‑L1 inhibitor BMS‑202 on A375 melanoma cells: Anti‑tumor activity accompanied by increased mitochondrial function.
Article Snippet: .. Materials. dMeM and 0.25% trypsin/edTa solution used for cell passing were purchased from Thermo Fisher Scientific, inc. BMS‐202 (cat. no. hY‐19745; Medchemexpress) is a non‐peptide inhibitor of the Pd‐1/Pd‐l1 complex that binds to Pd‐l1, effectively blocking the interaction between human Pd‐1 and Pd‐l1. gW604714X (gW; cat. no. hY‐138559; Medchemexpress) is a highly specific inhibitor of the mitochondrial pyruvate carrier, which markedly suppresses mitochondrial respiration. .. For western blotting, various primary antibodies were used including β‐tubulin (1:5,000; cat. no. Fd0064, hangzhou Fude Biotechnology co., ltd.), mitochondrial cytochrome c oxidase subunit 1 (MT‐co1; 1:1,000; cat. no. ab14705), Bax (1:100; cat. no. ab32503) and Bcl‐2 (1:1,000; cat. no. ab182858) (all from abcam), as well as horseradish peroxidase‐conjugated anti‐rabbit (1:1,000, cat. no. ab6721) and anti‐mouse (1:1,000, cat. no. ab6728) secondary antibodies (both from abcam). gaPdh (1:10,000; cat. no. 10494‐1‐aP), Mitochondrially encoded nadh dehydrogenase 4 (MT‐nd4; 1:1,000; cat. no. 26736‐1‐aP) and MT‐nd5 (1:1,000; cat. no. 66613‐1‐ig) antibodies were obtained from Proteintech group, inc.

Article Title: Direct effects of the small molecule PD-L1 inhibitor BMS-202 on A375 melanoma cells: Anti-tumor activity accompanied by increased mitochondrial function
Article Snippet: .. DMEM and 0.25% trypsin/EDTA solution used for cell passing were purchased from Thermo Fisher Scientific, Inc. BMS-202 (cat. no. HY-19745; MedChemExpress) is a non-peptide inhibitor of the PD-1/PD-L1 complex that binds to PD-L1, effectively blocking the interaction between human PD-1 and PD-L1. .. GW604714X (GW; cat. no. HY-138559; MedChemExpress) is a highly specific inhibitor of the mitochondrial pyruvate carrier, which markedly suppresses mitochondrial respiration.

Activity Assay:

Article Title: GPC3-mediated lysosome-targeting chimeras (GLTACs) for targeted degradation of membrane proteins
Article Snippet: .. Reversing the degradation activity of WP0 HepG2 cells were seeded in 6-well plates at a density of 3 × 105 cells per well and incubated at 37 °C, 5% CO2 for 24 h. Cells were pretreated with BMS-202 (MedChemExpress, Cat No. HY-19745, State of New Jersey, USA) (1 μmol/L), TJ12P1 (1 μmol/L), MG132 (Yeasen, Cat No. 52801ES08) (100 nmol/L), and bafilomycin A (Yeasen, Cat No. 53768ES76) (100 nmol/L) for 2 h, then treated with WP0 (1 μmol/L) for another 24 h. The changes in protein levels in cells were subsequently investigated by using Western blot analysis. ..

Incubation:

Article Title: GPC3-mediated lysosome-targeting chimeras (GLTACs) for targeted degradation of membrane proteins
Article Snippet: After washing with PBS 3 times, the fluorescence was observed and photographed using a confocal microscope (Leica, SP8, Germany). .. HepG2 cells were seeded in 6-well plates at a density of 3 × 10 5 cells per well and incubated at 37 °C, 5% CO 2 for 24 h. Cells were pretreated with BMS-202 (MedChemExpress, Cat No. HY-19745, State of New Jersey, USA) (1 μmol/L), TJ12P1 (1 μmol/L), MG132 (Yeasen, Cat No. 52801ES08) (100 nmol/L), and bafilomycin A (Yeasen, Cat No. 53768ES76) (100 nmol/L) for 2 h, then treated with WP0 (1 μmol/L) for another 24 h. The changes in protein levels in cells were subsequently investigated by using Western blot analysis. ..

Western Blot:

Saline:

Article Title: The Regulation of the PD-1/PD-L1 Pathway in Imiquimod-Induced Chronic Psoriasis Itch and Itch Sensitization in Mouse.
Article Snippet: Drug administration Primary antibodies for ionized calcium-binding adapter molecule 1 (Iba-1; 1:100, ab178847) and recombinant mouse PD-L1 (1 in 50 μL of saline, ab130039) were purchased from Abcam (San Francisco, CA, USA). .. The small molecule PD-1/PD-L1 inhibitors, BMS-1 (50 μg in 50 μL of saline, HY-19991) and BMS-202 (50 μg in 50 μL of saline, HY-19745) and PLX5622 in AIN-76A Diet (contains 1200 mg of PLX5622 per Kg of diet, HY-114153C) was purchased from MedChemExpress (Shanghai, China). .. Furthermore, the primary antibodies for PD-1 (1:200, 18106-1-AP) were purchased from Proteintech (Wuhan, China).

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